Effect of lost bite force on the expression of TNF-α in the rat periodontium

Objective To study the expression of TNF-α in the rat periodontal cells under normal and increased bite force,in order to explain the molecular mechanism of periodontium remodeling.Methods HE staining and immunohistochemistry techniques were applied to study the change in the histologic morphology and the expression of TNF-α protein.Results Under the increased bite force,periodontal ligament width was enlarged and alveolar bone was formed;the expression level of TNF-α increased apparently in periodontal cells.Conclusion Increased bite force induce the expression of TNF-α increased apparently in periodontium.It approached initially the molecular mechanism of periodontium remodeling,suggested that the histologic morphology is closely related to the mechanical condition.