Aspirin and Clopidogrel Low Responsiveness in Acute Coronary Syndrome

The rupture of unstable plaque and formation of thrombi is the basic pathological progression of acute coronary syndrome.Increasing numbers of clinical trials have shown that aspirin and clopidogrel treatments can reduce the prevalence of cardiovascular events like acute coronary syndrome in high risk patients,as well as the incidence of ischemic events in patients ready for percutaneous coronary intervention.However,there are approximately 1%~45% patients treated with aspirin and clopidogrel who still have ischemic events[1].Therefore,the variable responsiveness of patients treated with antiplatelet drugs has become an area of interest in clinical research.