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2006•Pharmaceutical biotechnologyRequires access

Biotransformation of L-Phenylacetylcarbinol (L-PAC) by Free Cells of Shizosaccharomyces pombe

XU Ji-yang

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Abstract

The yeast-mediated biotransformation of benzaldehyde and pyruvic acid to L-Phenylacetylcarbinol(L-PAC),a key intermediate for L-ephedrine synthesis,occurs in citrate buffer(pH6.0) containing 10% free yeast cells aged of 18h at temperature of 28℃.The highest L-PAC concentration of 15()g/L was achieved by adding 150mmol/L benzaldehyde with 180mmol/L pyruvic acid in batches.

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What this paper is about

The yeast-mediated biotransformation of benzaldehyde and pyruvic acid to L-Phenylacetylcarbinol(L-PAC),a key intermediate for L-ephedrine synthesis,occurs in citrate buffer(pH6.0) containing 10% free yeast cells aged of 18h at temperature of 28℃.The highest L-PAC concentration of 15()g/L was achieved by adding 150mmol/L benzaldehyde with 180mmol/L pyruvic acid in batches.

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Available abstract

The yeast-mediated biotransformation of benzaldehyde and pyruvic acid to L-Phenylacetylcarbinol(L-PAC),a key intermediate for L-ephedrine synthesis,occurs in citrate buffer(pH6.0) containing 10% free yeast cells aged of 18h at temperature of 28℃.The highest L-PAC concentration of 15()g/L was achieved by adding 150mmol/L benzaldehyde with 180mmol/L pyruvic acid in batches.

Key concepts: Biotransformation, Benzaldehyde, Chemistry, Yeast, Pyruvic acid, Biochemistry, Chromatography, Catalysis

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Biotransformation of L-Phenylacetylcarbinol (L-PAC) by Free Cells of Shizosaccharomyces pombe — Research Paper | ScholarLens