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2007•Zhongguo laonianxue zazhiRequires access

Effect of diltiazem on proliferation of VSMC

Xu Wang

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Abstract

Objective To investigate the effect of Diltiazem(Dil) on proliferation of vascular smooth muscle cells(VSMCs) induced in angiotensin Ⅱ(AngⅡ).Methods Thoracic aorta VSMCs cultured by tissue-sticking method were randomly divided into 5 groups:control,model and different concentrations of Dil groups(10-5,10-6 and 10-7 mol/L).The cell proliferation ability of VSMCs was measured by MTT assay,the cell generation cycle and prolifation index were measured by flow cytometery.Results Three concentrtions of Dil significantly inhibited the proliferation of VSMCs(P0.05),up-regulated the constituent ratio of VSMCs G0/G1 cell cycle(P0.05) and down-regulated the proliferation index significantly(P0.05).Conclusions Dil could inhibit the proliferation of VSMCs significantly.

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What this paper is about

Objective To investigate the effect of Diltiazem(Dil) on proliferation of vascular smooth muscle cells(VSMCs) induced in angiotensin Ⅱ(AngⅡ).Methods Thoracic aorta VSMCs cultured by tissue-sticking method were randomly divided into 5 groups:control,model and different concentrations of Dil groups(10-5,10-6 and 10-7 mol/L).The cell proliferation ability of VSMCs was measured by MTT assay,the cell generation cycle and prolifation index were measured by flow cytometery.Results Three concentrtions of Dil significantly inhibited the proliferation of VSMCs(P0.05),up-regulated the constituent ratio of VSMCs G0/G1 cell cycle(P0.05) and down-regulated the proliferation index significantly(P0.05).Conclusions Dil could inhibit the proliferation of VSMCs significantly.

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Available abstract

Objective To investigate the effect of Diltiazem(Dil) on proliferation of vascular smooth muscle cells(VSMCs) induced in angiotensin Ⅱ(AngⅡ).Methods Thoracic aorta VSMCs cultured by tissue-sticking method were randomly divided into 5 groups:control,model and different concentrations of Dil groups(10-5,10-6 and 10-7 mol/L).The cell proliferation ability of VSMCs was measured by MTT assay,the cell generation cycle and prolifation index were measured by flow cytometery.Results Three concentrtions of Dil significantly inhibited the proliferation of VSMCs(P0.05),up-regulated the constituent ratio of VSMCs G0/G1 cell cycle(P0.05) and down-regulated the proliferation index significantly(P0.05).Conclusions Dil could inhibit the proliferation of VSMCs significantly.

Key concepts: Vascular smooth muscle, Cell growth, Diltiazem, Cell cycle, Angiotensin II, Proliferation index, Aorta, Cell

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