2007•Journal of the Korean Ophthalmological SocietyRequires access
The Morphological Study of Muller Cells with Enzyme Histochemical Staining in Retina of Induced Diabetic Rats
Su Joung Mun, In‐Cheol Kim, Dong Wook Lee, Xin Hua, Nam Chun Cho
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Abstract
Purpose: To evaluate the morphological changes in Muller cells of an induced diabetic rat model with carbonic anhydrase histochemical staining. Methods: Retinae of three normal rats and four streptozotocin-induced diabetic rats were used. The morphological changes in the Muller cells of these retinae were observed using enzyme histochemical staining. Results: The numbers of positive staining Muller cells in diabetic rats retinae were significantly lower than those of the normal rats. In addition, the shape of the Muller cell bodies in the streptozotocin-induced diabetic rat model’s retina changed from polygonal to abnormally flat. Furthermore, the staining of the Muller cells’ segment in the outer nuclear layer of the diabetic rat’s retinae were weaker, and some Muller cell segments were not stained at all. Conclusions: The numbers of Muller cells in diabetic rats’ retinae were significantly lower than those of the normal rats. In addition, the features of Muller cell bodies of the diabetic rats were changed morphologically.