The expression of IL-1β、TNF-α、VEGF in the herniated lumbar disc

Objective: To study the expression of cytokines in tissues of different type of herniated lumbar disc. Methods: The tissues of herniated lumbar disc were obtained from 70 patients of lumbar interverte-bral disc herniation who received surgery, then detected the expression level of IL-1β, TNF-α and VEGF in the different type of herniated lumbar disc through immunohistochemical method, and 7 normal specimen of lumbar discs were regard as a control group. Results: Positively expressing cells of IL-1, TNF-α were presented in exinflate lumbar disc were 4(31%), 3(23%) and no VEGF was found. In herniated lumbar disc, positive expressions of IL-1, TNF-α were 27(69. 3%) , 25(64%) and no VEGF either. IL-1β, TNF-α and VEGF of protrusion lumbar disc were 14(89%) , 13(87%) and 2(12. 5%). Positive expressions of VEGF were also found in endothelial cell, but the positive rate was low. As to the tissue of 7 normal lumbar disc, positively expressing cells of IL-1β, TNF-α, VEGF were presented in 1, 2 and 0 specimens. Conclusion:The positive expressions of IL-1β, TNF-α have significant difference in different type of herniated lumbar disc, so the expressions of IL-1β, TNF-α, VEGF take an importat role in therapy and prognosis of herniated lumbar disc.