Comparison the sedative effect of Propofol and Midazolan during mechanical ventilation in ICU

Objective To study the difference of sedative effects of Propofol and Midazolam on patients with mechanical ventilation.Methods320 ICU patients with mechanical ventilation from Jan 2007 to May 2008 were divided into two groups,120 patients were given with Propofol and the other 200 patients with Midazolam.In Propofol group:Propofol(1.00~3.00 mg/kg)was injected intravenously as sedative induction before intubation,administer mechanical ventilation after intubation,followed by continuous injection intravenous 0.50~4.00 mg/(kg·h)using injecting pump.The duration of sedation was(25±5.6)hours.In Midazolam group:Midazolam(0.06~0.30 mg/kg)was injected intravenously as sedative induction before intubation,administer mechanical ventilation after intubation,followed by continuous injection intravenous 0.04~0.20 mg/(kg·h)using injecting pump.The duration of sedation was(28.5±6.4)h.ResultsThe time to take effect of propofol group was(15±5)seconds,compared with(63.1±10.3)seconds in Midazolam group,showing significant difference(P0.01).Grades 3~4 ramsay classification was reached in patients of both groups.The time needed to reach it was(20±15)min in the Propofol group and(30±15)min in Midazolam group.Performance of blood oxygen saturation,arterial partial pressure of oxygen,arterial carbon dioxide partial pressure and respiration were improved significantly for both group of patients.And there was no remarkable significance in differences between the two groups(P0.05).Consciousness recovery time after stopping drug:the Propofol group was(9.6±6.5)min and the Midazolam group was(55±10.7)min(P0.01).5 cases in Propofol group were recorded dropped blood pressue.ConclusionBoth Propofol and Midazolam have good sedative effects in ICU patients.