2009China Journal of Oral and Maxillofacial SurgeryRequires access

Neurotrophic factor delivery in nerve conduits for peripheral nerve regeneration

Zhi Zhang

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Abstract

Nerve Regeneration is a complex biological phenomenon incorporated by cells, growth factors and extracellular matrix. At present, bioengineering strategies for peripheral nerve regeneration are focused on designing and manufacturing reactive combined nerve conduits to mimic nerve autografts for better functional recovery. This review will present neurotrophic factor delivery systems applied in those conduits.

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What this paper is about

Nerve Regeneration is a complex biological phenomenon incorporated by cells, growth factors and extracellular matrix. At present, bioengineering strategies for peripheral nerve regeneration are focused on designing and manufacturing reactive combined nerve conduits to mimic nerve autografts for better functional recovery. This review will present neurotrophic factor delivery systems applied in those conduits.

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Available abstract

Nerve Regeneration is a complex biological phenomenon incorporated by cells, growth factors and extracellular matrix. At present, bioengineering strategies for peripheral nerve regeneration are focused on designing and manufacturing reactive combined nerve conduits to mimic nerve autografts for better functional recovery. This review will present neurotrophic factor delivery systems applied in those conduits.

Key concepts: Nerve guidance conduit, Regeneration (biology), Nerve growth factor, Neurotrophic factors, Peripheral nerve, Neurotrophin, Extracellular matrix, Neuroscience

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