Clinical study on Spirulina Capsules combined with paclitaxel and cisplatin in treatment of advanced cervical cancer

Objective To explore the clinical effect of Spirulina Capsules combined with paclitaxel and cisplatin in treatment of advanced cervical cancer. Methods The patients with advanced cervical cancer(90 cases) of Liaoning Cancer Hospital Institute from March 2011 to January 2014 were randomly divided into control and treatment groups, and each group had 45 cases. The patients in the control group were iv administered with Paclitaxel Injection 130 mg/m2 and Cisplatin for injection 60 mg/m2 on the first day of each chemotherapy cycle. The patients in the treatment group were po administered with Spirulina Capsules, 3 grains/time, three times daily, and other treatment was the same as the control group. One course of treatment was 21 d, and two groups were treated for four courses of chemotherapy. After treatment, the efficacy was evaluated, and the changes of KPS score and immune function indexes were compared. At the same time, drug adverse reactions of two groups were observed. Results After treatment, the total effective rate of control and treatment groups were 71.11% and 88.89%, respectively, and there were differences between two groups(P 0.05). After treatment, KPS score, CD3+, CD4+ in the treatment group were higher than those before the treatment, while CD8+ was significantly reduced, and the difference was statistically significant in the same group(P 0.05). After treatment CD3+, CD4+ were higher than those in the control group, and CD8+ was lower than that in the control group, and there were differences between two groups(P 0.05). The incidences of adverse reaction such as white blood cells and platelets reduced, nausea, vomiting, diarrhea, anemia, and inflammation of the oral mucosa were significantly lower than those in the control group. Conclusion Spirulina Capsules combined with paclitaxel and cisplatin can improve the clinical curative effect of advanced cervical cancer, and can improve the quality of life and immune function, while can reduce the adverse reaction of chemotherapy drugs, which is worth clinical popularization and application.