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2011•Chinese Journal of Birth Health & HeredityRequires access

Influence of NGF on neural stem cell Nogo-A expression after cerebral hypoxia ischemic in newborn rats

Xiaomei Wu

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Abstract

Objective:To study the effects of exogenous nerve growth factor(NGF) on expression of Nogo-A in the neonatal rat brain tissue after hypoxia ischemic brain damage(HIBD).Methods: 72 neonatal SD rats were divided randomly into NGF group,controlled group and sham-operated group,Immunohistochemistry method was used to measure the expressions of Nogo-A after in the neonatal rat brain tissue after hypoxia ischemic brain damage.Results:The expression of Nogo-A in the neonatal rat brain tissue in NGF group and controlled group increased at 3 d after hypoxia ischemic brain damage and reached the highest level at 21 d;the corrected optical density(COD) value of controlled group was significantly higher than that of the sham-operation group and NGF group(P0.05).Conclusion: The neuro-protective effect of NGF on the newborn rats with HIBD is related to the reduced expression of Nogo-A.

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What this paper is about

Objective:To study the effects of exogenous nerve growth factor(NGF) on expression of Nogo-A in the neonatal rat brain tissue after hypoxia ischemic brain damage(HIBD).Methods: 72 neonatal SD rats were divided randomly into NGF group,controlled group and sham-operated group,Immunohistochemistry method was used to measure the expressions of Nogo-A after in the neonatal rat brain tissue after hypoxia ischemic brain damage.Results:The expression of Nogo-A in the neonatal rat brain tissue in NGF group and controlled group increased at 3 d after hypoxia ischemic brain damage and reached the highest level at 21 d;the corrected optical density(COD) value of controlled group was significantly higher than that of the sham-operation group and NGF group(P0.05).Conclusion: The neuro-protective effect of NGF on the newborn rats with HIBD is related to the reduced expression of Nogo-A.

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Available abstract

Objective:To study the effects of exogenous nerve growth factor(NGF) on expression of Nogo-A in the neonatal rat brain tissue after hypoxia ischemic brain damage(HIBD).Methods: 72 neonatal SD rats were divided randomly into NGF group,controlled group and sham-operated group,Immunohistochemistry method was used to measure the expressions of Nogo-A after in the neonatal rat brain tissue after hypoxia ischemic brain damage.Results:The expression of Nogo-A in the neonatal rat brain tissue in NGF group and controlled group increased at 3 d after hypoxia ischemic brain damage and reached the highest level at 21 d;the corrected optical density(COD) value of controlled group was significantly higher than that of the sham-operation group and NGF group(P0.05).Conclusion: The neuro-protective effect of NGF on the newborn rats with HIBD is related to the reduced expression of Nogo-A.

Key concepts: Nerve growth factor, Hypoxia (environmental), Brain damage, Immunohistochemistry, Medicine, Internal medicine, Endocrinology, Cerebral hypoxia

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Influence of NGF on neural stem cell Nogo-A expression after cerebral hypoxia ischemic in newborn rats — Research Paper | ScholarLens