Serum TNF-α Changes in Severe Hepatitis Patients and the Clinic Value

Objective To investigate the mechanism and clinic value of TNF-α in SH, based on the observation of serum level of TNF-α in patients with various stages of SH and the change of serum level of TNF-α in SH after the therapy of ALSS.Methods Patients were divided into groups with severe hepatitis、acute hepatitis、chronic hepatitis、hepatic cirrhosis after hepatitis and control group. The serum level of TNF-α、 endotoxin and TGF-β 1 were detected in every group as well as severe hepatitis group before and after the therapy of ALSS.Result The level of serum TNF-α、endotoxin、and TGF-β 1 was notably higher than that in acute hepatitis group、chronic hepatitis group、control group, and decreased obviously after the therapy of ALSS(p0.05). Clinical condition of patients whose serum level of TNF-α decreased gradually improved step by step in severe hepatitis group.Conclusion High level of TNF-α in serum plays an important role in hepatocyte damage of severe hepatitis. ALSS can remove TNF-α. The changes of serum TNF-α level in patients with severe hepatitis can be used to judge the severity and the prognosis of severe hepatitis.