Effect of Amloclipine in patients with stable exertional angina

Objective:To assess the effects of amloclipine in patients with stable exertional angina.Method: The study included 54 stable exertional angina patients with two positive exercise tests within one week, and the difference of duration of exercise between two tests ≤10%. Amloclipine was combined with the β blockers or long acting nitrates. The total time for treatment was 8 weeks. Result: The results showed that amloclipine significantly increased total work load, time to onset of angina and time to 1 mm ST segment depression (P 0.01 ). After treatment,18 patients ( 33.34 %) didn't showed ST depression ≥1 mm during exercise, however, rate pressure product did not change significantly (P 0.05 ). Amloclipine reduced the number of anginal attacks and the mean nitrate consumption per week. During the period of amloclipine therapy, there were 5 cases with adverse effects reported( 9.25 %), but their symptoms were mild and it was unnecessary to withdraw the drug. Conclusion: For patients with stable exertional angina, Amloclipine increases the exercise capacity. The drug is safe and effective and well tolerated by patients.