Application of intravenous anesthesia with target-controlled infusion of Propofol and intravenous infusion of Remifentanil in tonsillectomy of children

Objective To compare with Sevoflurane anesthesia and explore the safety and effectivity of intravenous anesthesia with target-controlled infusion of Propofol and intravenous Infusion of Remifentanil in tonsillectomy of children.Methods 30 ASA Ⅰ～Ⅱ children undergoing elective tonsillectomy were randomly divided into two groups:Group P received intravenous anesthesia with target-controlled infusion of Propofol and Propofol were set at 4 μg/mL(n=15), Group S received Sevoflurane anesthesia(n =15).The hemodynamics during induction anaesthesia, intubation and the beginning of the operation were compared.The time of extubation and OAA/S scores at 10 min after extubation, incidence of agitation and incidence of nausea and vomiting were noted after operation.Results Patients exhibited lower medial blood pressure during induction of anaesthesia in group F than in group S(P 0.05).The occurance of intubation reaction were lower in group F;Patients exhibited higher medial blood pressure at the beginning of the operations in group S than in group P(P 0.05), but it had no difference in statistis.Time from stopping administration of anaesthetics until tracheal extubation were similar for two groups(P 0.05).The incidence of agitation and incidence of nausea and vomiting were low in both group.The scores of Assessment of alertness/sedation(OAAS) of group P at 10 minutes after tracheal extubation was higher than group S(P 0.05).Conclusions In tonsillectomy of children, intravenous anesthesia with target-controlled infusion of Propofol and intravenous infusion of Remifentanil is well tolerated, causing steady hemodynamics and resulting in a better recovery than Sevoflurane anesthesia.