Value of perfusion-weighted MR imaging in the preoperative grading of cerebral glioma

Objective:To evaluate the potential of rCBV and rCBV ratio in the grading of cerebral gliomas by perfusion weighted MR imaging (PWI).Methods:MR PWI was performed in 32 patients with cerebral glioma,including 11 cases of low-grade (grade Ⅰ～Ⅱ) and 21 cases with high-grade (grade Ⅲ～Ⅳ) glioma.The perfusion data were deconvoluted to get a map of rCBV.The maximal rCBV and rCBV ratio of each lesion was correlated with histopathologic grading of gliomas.Results:The rCBV and rCBV ratio in low-grade gliomas were 161.51±60.69 and 2.89±0.83 respectively,but 506.13±157.89 and 5.96±2.47 in high-grade glioma.There was significant difference in rCBV (P0.001) and rCBV ratio (P0.001) between the low-grade and high grade glioma.Conclusion:Significant difference in rCBV and rCBV ratio exists between gliomas of different grade.Perfusion weighted MR imaging is very useful in pre-operative grading of cerebral gliomas.