Comparison of dexmedetomidine or fentanyl combined with propofol target controlled infusion in the diagnosis and treatment of hysteroscopy

Objective To evaluate the safety and effect of dexmedetomidine or fentanyl combined with propofol target controlled infusion in the diagnosis and treatment of hysteroscopy. Methods 90 cases of patients who were taken hysteroscopin surgery were randomly divided into group D,F and N,0.5 μg/kg dexmedetomidine was pumped into group D within 10 min before anesthesia,1 μg/kg fentanyl was injected to group F,10 ml normal saline was injected to group N,propofol target controlled infusion was instantly given to the three groups,target concentration was adjusted according to the surgical stimulation and patient response.The mean arterial pressure(MAP),heart rate(HR),respiratory rate and oxygen saturation was observed before anesthesia(T0),5 min after the completion of propofol-induced(T1) and 5 min after surgery(T2);total amount of propofol,operation time,time of propofol infusion to the patient to stop calling eye opening was recorded;the effect of anesthesia,5 min after awakening visual analog scale(VAS) was evaluated. Results The operation time,recovery time in group D and F was significantly shorter than that in group N,the amount of propofol was significantly less than that of group N(P0.05);there was no significant difference between group D and F(P0.05).MAP,HR of 3 groups at T1and T2significantly decreased compared with T0(P0.05),and there was significant difference between group D,F compared with group N and group D compared with group F(P0.05).The minimum value of oxygen saturation in group D and F was significantly higher than that in group N(P0.05),and there was no significant difference between group D and group F(P0.05);the effect of anesthesia and 5 min VAS after awakening in group D,F was better than that in group N(P 0.05). Conclusion 0.5 μg/kg dexmedetomidine or 1 μg/kg fentanyl combined with propofol is more safely and effective for diagnosis and treatment of hysteroscopy surgery than single-applied propofol.