Comparative Study on Simultaneous Determination of Pb,Cd,As in Blood by ICP-MS

OBJECTIVE To establish a rapid and accurate method for instantaneous analysis of Pb,Cd,As in blood by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). METHODS The assay method was established according to comparative study of standard curve method and standard addition curve method (a method derived and developed from standard addition method). RESULTS Both methods showed good correlative coefficients of calibration curve,limits of detection and reproducibilities for all test elements. Standard curve method,indicated unsatisfactory spiked recovery between 92.00% and 135.0%,as well as unacceptable determined values of reference materials (GBW09139e and GBW09140e). Standard addition curve method indicated satisfactory spiked recovery range from 93.33% to 102.0% and coincident contents of reference materials. CONCLUSION Standard addition curve method,bearing better spiked recovery and precise than those of standard curve method,was a rapid and accurate method for simultaneous determination of harmful elements in blood by ICP-MS.