Celecoxib in the histological grade of chemically induced mammary tumor in rats

OBJECTIVE:To evaluate the impact of celecoxib,a selective cyclooxygenase-2 inhibitor,on the histological grades of chemically induced mammary tumor and normal mammary tissue in rats.METHODS: Single dose of 7,12 dimethlbenz anthracene,DMBA) was administered i.g.into female SD rats to induce mammary tumors,during which various dose levels of celecoxib was dosed.The incidence,number and size of tumor were recorded,and mammary tumors and normal mammary tissues were analyzed via pathological observation.RESULTS: Compared with control group,100 mg/kg and 150 mg/kg celecoxib treatment groups had significantly decreased incidence and number of tumor,while comparable tumor size.More importantly,celecoxib could significantly reduced histopathological grades of both mammary tumors(100 mg/kg,P=0.021;150 mg/kg,P=0.036) and DMBA caused lesions in mammary lobule and alveolus(100 mg/kg,P=0.004).CONCLUSIONS: Prophylactic administer of celecoxib can reduce pathological grade of chemically induced rat mammary tumor,as well as protecting normal mammary tissues.Its clinical application is worthy of further investigation.