2009•Di-Si Junyi Daxue xuebaoRequires access
Protective effects of endothelin-1 mRNA antisense oligodeoxynucleotide on the kidney ultrustructure of streptozotocin-induced diabetic nephropathy rats
Jian Ping Yu
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Abstract
AIM:To investigate the protective effects of endothelin-1 mRNA antisense oligodeoxynucleotide(ET-1 AS-ODN)on the renal morphology of diabetic nephropathy(DN)and discuss the pathogenesis and mechanism of DN in a diabetic rat model.METHODS:Diabetic rats were induced by intraperitoneal administration of streptozotocin(STZ)at 60 mg/kg.ET-1 AS-ODN was administrated intravenously to the treatment groups and its protective effects on renal morphology were observed.RESULTS:Compared with the DM group,the kidney index reduced significantly the general condition and morphological injury improved significantly in ET-1 AS-ODN treatment groups.CONCLUSION:Endothelin-1 mRNA antisense oligodeoxynucleotide has a protective effect on the kidney by preventing renal impairment in diabetic nephropathy rats.The mechanism of the protective effect of Endothelin-1 mRNA antisense oligodeoxynucleotide involves inhibition of endogenous ET-1 production.