Significance of Expression of CD_(14)~+ CD_(16)~+ on Peripheral Monocytes in Children with Kawasaki Disease

Objective To observe the significance of expressions of CD14+CD16+ on peripheral monocytes in children with Kawasaki di-sease (KD).Methods The expression of CD14+ and CD14+CD16+ monocytes in 16 children with KD (1-11 years old) were analyzed by flow cytomety both pre-treatment and post-treatment.And the percentages of CD14+CD16+ monocytes among CD14+ monocytes were calculated.Sixteen healthy children (10 months -10 years old) were served as normal control group.Statistical analysis was performed using t test.Results The levels of CD14+ monocytes,percentage of CD14+CD16+ monocytes among CD14+ monocytes and CD14+CD16+ monocytes in children with KD during acute phase (n=16) were (1.03±0.58)×109 L-1,(12.53±5.31)% and(1.20±0.79)×108 L-1.They were significantly higher than those in the normal controls[(0.57±0.21)×109 L-1,(3.86±1.84)% and (0.21±0.10)×108 L-1](Pa0.05).Followed by the patients' condition improved(n=15), the increased expressive levels[(1.03±0.60) ×109 L-1,( 12.83±6.51)%,(1.22±0.82)×108 L-1] decreased [(0.49±0.21)×109 L-1,(5.07±4.77)%,(0.24±0.20)×108 L-1)(Pa0.01)].The expressive levels of CD14+CD16+ monocytes were no significant differences between the post-treatment and the normal controls(Pa0.05).And the expressive levels remained high when the patient recurred.Conclusions The expressive levels of CD14+CD16+ monocytes increase in children with KD.And they change when the patient's clinical condition change.