The contrast study of serum liver fibrosis indexes and liver pathology

To evaluate the clinical value of serum fibrosis index in the diagnosis of hepatic fibrosis. 69serum samples from patients with chronic hepatitis B were detected by RIA and EIA for fibrosis indexes including HA, PⅢP, LN and Ⅳ-C. liver biopsy were performed in all patients. Ⅳ-C,HA,PⅢP correlate positively with stage of fibrosis (r=0.663 P0.01;r=0.302 P0.01;r=0.346 P0.05)。ROC analysis showed that the AUCs of HA,Ⅳ-C,PⅢP, and LN were 0.745、0.909、0.732、0.425,respectively, when S=4 as positive criteria for diagnosing early liver cirrhosis. The sensitivity Ⅳ-CPⅢPHALN, the specificity HAⅣ-CPⅢPLN. Serum fibrosis index can predict the tendency of hepatic fibrosis.