2000•Zhongguo bingli shengli zazhiRequires access

Differentiation-inducing effects of baicalin on HL-60 leukemia cells

Buyuan Chen, 胡建达, Xinji Chen, l lian-huang

Abstract

AIM:To investigate the differentiation-inducing effects of baicalin on HL-60 leukemia cells.METHODS:The effect of baicalin on differential induction in AML cell line HL-60 was evaluated by cellular morphology,clone formation assay,CD11b and CD33 expression and NBT assay.RESULTS:Baicalin inhibited the proliferation of HL-60 cells.It enhanced the expression of CD11b on HL-60 cells,also increased the expression of CD33.HL-60 cells showed differentiation morphology after the drug treatment examined by Wright-Gimesa staining and NBT assay.CONCLUSION:Baicalin possessed differentiation-inducing effects on HL-60 cells.

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Key concepts: Baicalin, CD33, clone (Java method), Cellular differentiation, Molecular biology, Chemistry, Cell culture, Integrin alpha M