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ER-α36:a novel variant of human estrogen receptor-α

Bin Chen

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Abstract

Estrogen receptors(ERs),belonging to the nuclear receptor superfamily,mainly include ER-α66,ER-α36,ER-α46 and ER-β.Each of them performs specific functions by binding to its ligand such as estrogen.Recently,ER-α36,a novel variant of human estrogen receptor-alpha(ER-α) was identified and cloned.ER-α36 primarily localizes to the plasma membrane and cytoplasma and inhibits the transactivation of both ER-α66 and ER-β.Being predominantly a membrane-based ER,it mediates non-genomic estrogen signaling and involves in resistance to endocrine therapy such as tamoxifen in breast cancer.

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What this paper is about

Estrogen receptors(ERs),belonging to the nuclear receptor superfamily,mainly include ER-α66,ER-α36,ER-α46 and ER-β.Each of them performs specific functions by binding to its ligand such as estrogen.Recently,ER-α36,a novel variant of human estrogen receptor-alpha(ER-α) was identified and cloned.ER-α36 primarily localizes to the plasma membrane and cytoplasma and inhibits the transactivation of both ER-α66 and ER-β.Being predominantly a membrane-based ER,it mediates non-genomic estrogen signaling and involves in resistance to endocrine therapy such as tamoxifen in breast cancer.

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Available abstract

Estrogen receptors(ERs),belonging to the nuclear receptor superfamily,mainly include ER-α66,ER-α36,ER-α46 and ER-β.Each of them performs specific functions by binding to its ligand such as estrogen.Recently,ER-α36,a novel variant of human estrogen receptor-alpha(ER-α) was identified and cloned.ER-α36 primarily localizes to the plasma membrane and cytoplasma and inhibits the transactivation of both ER-α66 and ER-β.Being predominantly a membrane-based ER,it mediates non-genomic estrogen signaling and involves in resistance to endocrine therapy such as tamoxifen in breast cancer.

Key concepts: Estrogen receptor, Transactivation, Estrogen receptor alpha, Estrogen receptor beta, Estrogen, Estrogen-related receptor gamma, PELP-1, Tamoxifen

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