2004•Zhejiang Journal of Integrated Traditional Chinese and Western MedicineRequires access

Study on the Gene Expression of Kanglaite of Anti-Cancer Cachexia of Mouse

Yufei Yang, Wu Yu, Wu Donghua, Yuzhi Wang, Jing Wang

Abstract

Objective: To screen the differential expression genes of Kanglaite Injection in treating cancer cachexia. Methods: mRNA was extracted from the blood cells of T739 animal model of C.C., hybridizated respectively on 20S gene chip. Analysis discuss on differential expression genes was carried out. Results: 5 differential expression genes were obtained. Among these genes, 4 genes were up-regulated and 1 gene was down-regulated. Most of these genes were related with immunity and metabolism of tumor. Conclusion: cDNA microarray for analysis of gene expression patterns is a powerful method to identify associated genes of Kanglaite.

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Key concepts: Cancer cachexia, Gene, Gene expression, Microarray, Complementary DNA, Medicine, Microarray analysis techniques, Messenger RNA