2003•Journal of Henan UniversityRequires access

The Study on Condensation Reaction Kinetics of Synthesizing Trimethoprim from Trimethoxy-benzaldehyde

Qui Dong

Abstract

In the course of condensation reaction of systhesizing trimethoprim(TMP) from trimethoxybenzaldehyde, the contents of material trimethoxybenzaldehyde(TMB) and condensation product in the reaction system are analyzed by high performance liquid chromatography(HPLC).Kinetics equations at 298.15K and at 308.15K are deduced, with the reaction series of TMB of 0.37.Apparent activation energy is 71.73kJ·moL-1.

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Key concepts: Benzaldehyde, Chemistry, Condensation reaction, Condensation, Kinetics, Activation energy, Organic chemistry, Medicinal chemistry