The correlation between genotypes at the position-889C/T in the promoter of interleukin-1 alpha and coronary heart disease in Gansu province Han population

Objective To investigate the correlation between the different genotypes at the position889C/T in the promoter of interleukin-1α(IL-1α) and the severity of coronary heart disease(CHD). MethodsThe genotype of IL-1α(-889C/T) from 98 patients with CHD and 131 healthy controls were analyzed by polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP). ResultsThe frequence of genotype CC in Gansu province Han population were 183/229(79.9%),CT 45/229(19.7%) and TT 1/229(0.04%).The frequence of allele C was 411/458(89.7%),T 47/458(10.3%).A significant increase was found for the IL-1α genotype CT in CHD patients compared with controls(P0.01).There was significant difference in genotype CT between myocardial infarction group and controls(P0.01).But there was no significant difference in genotype CT between angina pectoris group and controls(P0.05).The relative risk of myocardial infarction group with genotype CT was 2.02 times to angina pectoris group(odds ratio =2.02,95% confidence interval : 1.05-3.89,P0.05). ConclusionsThe polymorphism of genotypes C/T at the position -889 in the promoter of IL-1α is present and T allele may be a major risk factor for myocardial infarction patients in Gansu Han population.