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[Preparation of stearic acid solid lipid nanoparticles containing podophyllotoxin].

Fang-ming Xie, Kang Liang Zeng, Guofeng Li, Zhong-fang Lin, Ledong Sun

Abstract

OBJECTIVE: To improve the therapeutic efficacy and reduce the adverse effect of podophyllotoxin (PPT) by wrapping it in stearic acid solid lipid nanoparticles. METHODS: Stearic acid solid lipid nanoparticles containing podophyllotoxin was prepared using modified microemulsion technique, whose morphology was examined by transmission electron microscope. High-performance of liquid chromatography was employed to determine the entrapment efficiency of PPT in the nanoparticles. RESULT: The entrapment efficiency of PPT in the nanoparticles was 85.6% and the mean diameter of the particles was 56.5+/-25.8 nm. CONCLUSION: The stearic acid solid lipid nanoparticles has high entrapment efficiency for PPT and is homogeneous in size, which can be a promising targeted preparation for epidermal delivery.

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Key concepts: Stearic acid, Solid lipid nanoparticle, Podophyllotoxin, Nanoparticle, Chemistry, Chromatography, Transmission electron microscopy, Materials science