Influence of Nicotinylmethylamide on the Pharmacokinetics Parameters of Cyclosporin A

OBJECTIVE: To study the influence of Nicotinylmethylamide (BILOCID) on the pharmacokinetics parameters of Cyclosporin A (CsA). METHODS: Whole blood CsA concentrations were measured by a fluorescence polarization immunoassay (FPIA) in 18 healthy volunteers administrated single CsA or co-administrated bil ocid. The data of time-blood concentrations of CsA were analyzed by 3P97 Practical Pharmacokinetics Program and the analysis of variance and two one-sided t-test were used to compare the main pharmacokinetics parameters of CsA in the two administrations. RESULTS: The results implied that Cmax and AUC(0-∞) ofCsA had statistically significant difference between the single CsA group and co-administration of bil ocid group (P0.001), while t1/2(β) and tmax of CsA had no statistically significant difference between the two groups (P0.05). CONCLUSION: bil ocid could improve the absorption of CsA and increase the Cmax and AUC of CsA, but had no influence on the metabolism of CsA.