2012•Unpublished venueRequires access

Pharmacokinetics study of α-asarone intravenous emulsion in rats

Shujun Wang

Abstract

Objective To compare the pharmacokinetics of α-asarone intravenous emulsion and aqueous solution for injection.Methods HPLC was used to determine the drug concentration in rat plasma after intravenous administration of emulsion and solution of α-asarone.The pharmacokinetic parameters were calculated using DAS 2.0 software.Result The plasma concentration-time profiles of emulsion and solution of α-asarone were similar after intravenous administration.Conclusion The plasma concentration-time profiles of α-asarone in emulsion and solution were similar,two preparations were bioequivalent.

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Key concepts: Bioequivalence, Pharmacokinetics, Emulsion, Chromatography, Chemistry, Plasma concentration, Pharmacology, Aqueous solution