2010•Medical RecapitulateRequires access
Progress in Calpains Activation and Association with Apoptosis
Liu Tang-we
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Abstract
Calpains is a family of calium-dependent intracellular neutral cysteine proteases,calpains activation in cells usually is induced by increase of Ca2+ concentration.Recently,calpains are considered to play an important role in apoptosis as experimental data suggested that calpains cleaved many important regulators of apoptosis pathway such as Bcl-2,Bax,Bid and p53,cleave and activate directly caspase-3 or caspase-7.then result cellular apoptosis.