Clinical Study Of Relationship Between Large Arterial Distensibility \;and Left Ventricular Structure and Function In Hypertension

Aim:To investigate the changes of large arteries ,left ventricular structure and function during hypertension; explore the clinical factors that influence these changes; analyze the relationship between the changes of large artery and the alteration of heart. Methods:Pulse wave velocity(PWV) measement ,color doppler and two dimensional echocardiography were used to study carotid femoral PWV and left ventricular structure and Results:PWV in hypertensive patients were higher(11.3±2.3 m/s),left ventricle mass index(LVMI) were in normal range(99.9±31.4 g/m 2),ejection fraction were normal(0.67±0.08),ratio of peak early mitral diastolic velocity(PE) and peak late mitral diastolic velocity(PA) were lower(0.97±0.3). Mutiple stepwise regression analysis demonstrated systolic blood pressure(SBP, P =0.0001), age( P =0.2371), PA ( P =0.0016) were main factors that influence PWV ,the change of PWV was closely related to LVMI. Conclusion:Large arterial distensibility decreased during hypertension,which was closely related to the change of left ventricular structure. The change of large arterial distensibility had close relationship with SBP level,age and left ventricular diastolic function.