Multicenter,blind,randomized clinical trial of ceftizoxime sodium injection in the treatment of acute bacterial infection

Objective To evaluate the efficacy and safety of ceftizoxime sodium injection in the treatment of acute bacterial infection. Methods A multicenter ,blind ,randomized clinical trial was carried. Imported ceftizoxime sodium was as the controlled drug. A total of 122 patients (61 trial and 61 control) were enrolled in this study. Ceftizoxime sodium injection was intravenously at a dose of 2 g bid for 5～10 days .The Imported ceftizoxime sodium was administered in same way,same dose and same course of treatment.Results At the end of treatment ,the cure rate were 75.41% and 80.33% (P0.05) in trial and control respectively.The effective rate were 96.72% in both two groups . The bacterial eradication rate for trial and control groups were 98.25% and 100%(P0.05), respectively. The incidence of adverse reaction were 6.25% and 9.38%(P0.05), respectively.Conclusion Ceftizoxime sodium injection was effective and safe drugs for acute bacterial infection.