The Expression and Its Clinical Significance of MMP-2 and NM23 in the Tissues from Non-Small Cell Lung Cancer and the Paracancerous Tissues

Objective To evaluate the expression and its clinical significance of MMP-2 and NM23 in patients with non-small-cell lung cancer.Methods The expression of MMP-2 and NM23 was detected by immunohistochemical method.Results Positive expression of MMP-2 in NSCLC tissues was observed in 29 of the 57(50.8%)and positive expression of NM23 was detected in 30 of 57(52.6%),respectively.MMP-2 and NM23 expression in NSCLC were not associated with patient's age,gender and pathologic classification(P0.05).The expression of MMP-2 in NSCLC was associated with clinical and pathologic staging(P0.05),while MMP-2 expression was negatively correlated with the node metastasis.Conclusion MMP-2 and NM23 both might be involved in the oncogenesis,development of non-small-cell lung cancer.Combined detection of MMP-2 and NM23 may be useful in the evaluation of the metastasis and prognosis of the patients.