Factors influencing glomerular filtration rate in patient with essential hypertension

Objective: To analyze the factors influencing glomerular filtration rate in patient with essential hypertension. Methods: Ninety-five patients with essential hypertension (EH) penformed 99mTc diethylentriamine pentaacetic acid( 99mTc-DTPA) renal dynamic imaging and were classified into two groups glomerular filtrationrate (GFR) reduction group (n=53) and GFR normal group (n=42) The age, duration of EH, lipid, blood urea nitrogen (BUN), creatinie (Cr), uric acid(UA), fibrinogen (Fib), microalbuminurin (MAU), α 1-microglobulin(α 1-MG), maxsystolic blood pressure(maxSBP), maxdiastolic blood pressure(maxDBP) and effective renal plasma flow( ERPF) between the two groups were studied by independent samples T Test. Rgression analysis were used to find the related factors of EH that had had GFR reduction. Results: The age and duration were significantly higher GFR reduction group than that of GFR normal group(P 0.01). The level of BUN, Cr, UA,α 1-MG, maxSBP, max-DBP were significantly higher GFR reduction group than that of GFR normal group(P 0.01). Regression analysis showed that ERPF was positive correlation with GFR(P 0.01), maxDBP was negative correlation with GFR (P 0.01). Conclusion: GFR reduction in patients with EH were results of maltiple factors.