Clinical Observation of Esmolol in the Treatment of Sympathetic Storm with Intravenous Administration

OBJECTIVE:To observe the clinical efficacy and safety of esmolol in the treatment of sympathetic storm with intravenous administration.METHODS:48 patients with sympathetic storm admitted were divided into 2 groups.20 patients in control group were given conventional intravenous administration of amiodarone and treatment of electrical cardioversion;on the basis of control group,28 patients in intervention group were given esmolol 0.5 mg/kg(intravenous injection within 1 min) and continuous intravenous infusion at 0.05-0.2 mg(/kg·min) which was reduced or discontinued depending on the disease condition.The success rate of terminating ventricular tachycardia or fibrillation,the number of electrical cardioversion as well as heart failure,primary deterioration of heart failure,bradycardia arrhythmias,hypopiesia were all observed in 2 groups.RESULTS:The number of electrical cardioversion in intervention group was less than control group,and the effective rate of terminating ventricular tachycardia or fibrillation in intervention group was 92.86%,which was significantly higher than 35.00% in control group;there was statistical significance(P0.05).There were no significant differences in the difference of heart failure,primary deterioration of heart failure,hypopiesia and bradycardia between 2 groups(P0.05).CONCLUSIONS:Intravenous injection of esmolol is beneficial and safe.