2009•Zhiye yu jiankangRequires access

A Comparative Study of Mirtazapine in Treatment of Post-stroke Depression

Weihong Zhang

Abstract

[Objective]To evaluate the efficacy and safety of mirtazapine in Treatment of post-stroke depression(PSD).[Methods]Totally 58 Patients with PSD were randomly divided into mirtazapine group(29 cases) and maprotiline group (29 cases)for 6 weeks treatment. Hamilton's depression scale (HAMD) and Emergent Symptom Scale (TESS) were used to assess the clinical efficacy and side effects.[Results]The obvious effective rate of mirtazapine was 75.9% and that of maprotiline was 72.4%, the effective time of mirtazapine group was earlier than that of maprotiline group. Less and slight side effect was found in mirtazapine group.[Conclusion]Mirtaznpine is a safe and effective antidepressants drug, with good toleration, less side effect and widely application, which can be used as the first choice for treatment of PSD.

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Key concepts: Mirtazapine, Hamd, Maprotiline, Medicine, Depression (economics), Post-stroke depression, Hamilton depression scale, Side effect (computer science)