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Effect of Heme Oxygenase-1 on Atherosclerosis in Rats

Xia Hao

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Abstract

Objective: To explore the inhibition mechanism of heme oxygenase-1(HO-1) on the progress of atherosclerosis in rats.Methods: Thirty male SD rats were randomly divided into three groups as control group,model group and hemin group.After three months,the serum concentrations of C-reaction protein(CRP) and interleulin-6(IL-6) of each group were measured.The expression of HO-1 and CD68 was measured by immunenhistochemistry.Results: Compared with that respectively in the control group,the CRP,IL-6,HO-1 and CD-68 in the model group and the hemin group increased significantly(P0.05).Compared with that in the model group,HO-1 of the hemin group increased significantly(P0.01),while the RAAPI,MDA,CD68 and MMP-9 decreased(P0.05).Conclusion: Heme oxygenase-1 can prevent atherosclerotic progression through inhibiting the inflammatory factors and decreasing the macrophages number,accordingly inhibiting the inflammatory response.

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What this paper is about

Objective: To explore the inhibition mechanism of heme oxygenase-1(HO-1) on the progress of atherosclerosis in rats.Methods: Thirty male SD rats were randomly divided into three groups as control group,model group and hemin group.After three months,the serum concentrations of C-reaction protein(CRP) and interleulin-6(IL-6) of each group were measured.The expression of HO-1 and CD68 was measured by immunenhistochemistry.Results: Compared with that respectively in the control group,the CRP,IL-6,HO-1 and CD-68 in the model group and the hemin group increased significantly(P0.05).Compared with that in the model group,HO-1 of the hemin group increased significantly(P0.01),while the RAAPI,MDA,CD68 and MMP-9 decreased(P0.05).Conclusion: Heme oxygenase-1 can prevent atherosclerotic progression through inhibiting the inflammatory factors and decreasing the macrophages number,accordingly inhibiting the inflammatory response.

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Available abstract

Objective: To explore the inhibition mechanism of heme oxygenase-1(HO-1) on the progress of atherosclerosis in rats.Methods: Thirty male SD rats were randomly divided into three groups as control group,model group and hemin group.After three months,the serum concentrations of C-reaction protein(CRP) and interleulin-6(IL-6) of each group were measured.The expression of HO-1 and CD68 was measured by immunenhistochemistry.Results: Compared with that respectively in the control group,the CRP,IL-6,HO-1 and CD-68 in the model group and the hemin group increased significantly(P0.05).Compared with that in the model group,HO-1 of the hemin group increased significantly(P0.01),while the RAAPI,MDA,CD68 and MMP-9 decreased(P0.05).Conclusion: Heme oxygenase-1 can prevent atherosclerotic progression through inhibiting the inflammatory factors and decreasing the macrophages number,accordingly inhibiting the inflammatory response.

Key concepts: Hemin, Heme oxygenase, Heme, CD68, Oxygenase, Internal medicine, Endocrinology, Inflammation

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