Effect of Compound Bulbus Allii Macrostemi Capsule on Pathology of Monocrotaline-induced Pulmonary Artery Hypertension in Rats

OBJECTIVE To investigate into the effect of Compound Bulbus Allii Macrostemi Capsule on the pathology of arteriole,right ventricle and lung tissue of rats with hypertension induced by monocrotaline(MCT).METHOD 84 SD(Sprague-Dawley) rats were randomly divided into 7 groups: a normal group of 10 rats,a model group of 14 rats,a Guilong Kechuanning group of 12 rats,a methylprednisolone group of 12 rats,a captopril group of 12 rats,a Compound Bulbus Allii Macrostemi Capsule high dosage group of 12 rats and a Compound Bulbus Allii Macrostemi Capsule low dosage group of 12 rats.Peritoneal monocrotaline injection(60 mg/kg) was given.The normal control group was given saline injection of the same dosage.Twenty-one days after the injection,six rats were taken randomly from each group to receive determination of average pulmonary artery pressure(mPAP) and average right ventricle pressure(mRVP).Eight rats was taken randomly from each group to observe pathological and morphological changes in the arteriole,the right ventricle and the lung tissue.RESULT Compared with the control group,mPAP and mRVP in the model group increased markedly,with marked statistical significance(P0.01),arteriole and right ventricle thickened markedly,the cavity of the arteriole narrowed or even closed and there was marked infiltration of inflammatory cells of the lung tissue.In the Guilong Kechuanning group,the methylprednisolone group,the captopril group,the Compound Bulbus Allii Macrostemi Capsule high dosage group and the Compound Bulbus Allii Macrostemi Capsule low dosage group,mPAP and mRVP dropped markedly,with marked statistical significance(P0.05 or P0.01),arteriole and right ventricle thickened markedly,the cavity of the arteriole narrowed or even closed,and the infiltration of inflammatory cells of the lung tissue was relieved.CONCLUSION Compound Bulbus Allii Macrostemi Capsule can effectively relieve MCT-induced pulmonary hypertension in rats,the possible mechanism of which may lie in the inhibition and improvement of reconstruction of arteriole and right ventricle,the relief of inflammatory cell infiltration and the effective reduction of pulmonary pressure and right ventricle pressure.This study indicates that Compound Bulbus Allii Macrostemi Capsule is a promising recipe for the treatment and prevention of pulmonary hypertension and further study is indicated.