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[Effects of hypothyroidism on Goalpha gene expression in hippocampus and dentate gyrus during early development of rat brain].

Cai Ds, Y Chen, G Chen, Minna Luo

Abstract

AIM: To study the expression of Goalpha mRNA in hippocampus and dentate gyrus of 7-day rats with hypothyroidism. METHODS: We use wistar rat model of hypothyroidism and non-radioactive in situ hybridization technique to observe the changs of Goalpha mRNA levels in hippocampus and dentate gyrus of 7-day rats with or without hypothyroidism. RESULTS: Perinatal hypothyroidism can increase Goalpha mRNA levels in all areas of hippocampus and dentate gyrus of 7-day rats. CONCLUSION: Thyroid hormone can down-regulate Goalpha gene transcription in hippocampus and dentate gyrus during the early development of rat brain.

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Key concepts: Dentate gyrus, Hippocampus, Internal medicine, Endocrinology, In situ hybridization, Thyroid, Messenger RNA, Neuroscience