Clinicopathologic analysis CD5-positive diffuse large B-cell lymphoma

Purpose To explore the clinical and pathological characteristics and clinical prognostic significance of CD5-positive diffuse large B-cell lymphoma(DLBCL). Methods 13 cases of CD5-positive DLBCL patients with clinical data,histological features,immunohistochemical staining results and clinical follow-up were analysed,the related literatures were reviewed. Results All 13 cases of CD5-positive DLBCL were also positive for pan B cell antigen(CD20,CD79a). Histologically,9 cases were centroblastic cell variant,2 cases were immunoblastic variant,2 cases were anaplastic variant. R-CHOP treatment program was selected,7 cases were complete remission,partial remission in 2 cases,progression in 1 case,3 cases untreated. After 4 ~ 46 months follow-up,3 patients died,9 cases were well,1 was lost. Conclusions CD5-positive DLBCL are rare with a higher age and poor prognosis,which need new treatments to prolong the patient's life.