Analysis of prognosis on patients with severe hepatitis using the criterion of model for end-stage liver disease

Objective To study the practical use of the model for end-stage liver disease(MELD) on clinic to assess its validity in predicting the prognosis of the patient with severe hepatitis.Methods 121 patients were divided randomly into plasma exchange group and none plasma exchange group,and they were graded with MELD formula.The death rate was observed within three months.Results 81 patients were died within 3month(35 cases in PE group,46 cases in non-PE group).The mortality of patients in PE group whose MELD score between 20～30 and 30～40 were 36.8%and 57.7%respectively;but in non-PE cases they were 64.9%and 87.5%respectively.There were significant differences between PE group and non-PE group(P0.05).However,the mortality of patients whose MELD score higherthan 40 were 86.7%in PE group and 100%in non-PE group,there were no significant difference between the two groups(P0.05).Conclusions This study suggests that the MELD score can be act as a disease's severity index for patients with severe hepatitis,and the mortality of the patient increases with the increase in the MELD score.The MELD can accurately predict the short-termprognosis of patients with severe hepatitis.