Relationship between blood pressure variability and microalbuminuria in elderly patients with hypertension

Objective To explore the relationship between blood pressure variability(BPV) and microalbuminuria(MAU) in elderly patients with primary hypertension.Methods A total of 61 cases initially diagnosed of stageⅠor Ⅱelderly primary hypertension were enrolled as EH group.Another 24 healthy subjects over 65 years old were chosen as control group.The 24 h ambulatory blood pressure was measured.Mean value and standard deviation(SD) of 24 h,day systolic blood pressure(SBP) and diastolic blood pressure(DBP) were compared between the two groups.The level of microalbuminuria(MAU) was regarded as an indicator for early renal injury.Relationship between BPV and MAU were analyzedd.The EH group was further divided into high BPV group(n=29) and low BPV group(n=32) according to the 50th SD percentile of the 24 h SBP variability,and the risk factors were compared between the two groups.Results The 24 h SBP and DBP variability and the day SBP variability were significantly higher in EH group than those in control group(P0.01).Bivariate correlative analysis showed that the night,24 h SBP and DBP in EH group were positively correlated with MAU(r = 0.264-0.492,P0.05).The age and the level of MAU were significantly higher in high BPV group than those in low BPV group(P0.05) Conclusions Variabilities of the night,24 h SBP and DBP is significantly related with MAU in the elderly patients with primary hypertension.It is helpful for prevention of early renal injury to reduce the level of BPV.