An experimental study of intestinal permeability and injury in the intestinal mucosa in acute necrotizing pancreatitis

Objective:The changes of intestinal permeability and relationship of intestinal mucosa and bacterial translocation were studied in rat ANP models.Methods:41 Wistar rats were divided into two group,model group(n=21) and control group(n=20).The intestinal permeability was observed by lanthanum tracer under eletron microscope.Results:The pathologic lesions were found in the intestinal villus of the ANP group,including acute necrosis of intestinal mucosa and increased permeability of intestinal mucosa and enterocytes.Bacterial translocation to organs and ascites could be found in all animals of ANP group.Conclusions:The results demonstrated that there was a severe gut barrier damage and injury in the intestinal mucosa,which led to bacterial translocation from intestine as the source of pancreatic infection.