The relationship between folate metabolism Related Gene and Birth Defects,Poor Pregnancy

More and more study shown that folate had important role in the birth defects such as congenital heart disease and neural tube defects,adverse pregnancy such as premature birth and abortion.However,promotion folic acid fortification will artificially lead to future population dependent on a large number of vitamin,lead to the overall gene composition changed,the crowd will become very fragile to a fatal disease,folate level in whose is lower than that in normal persons.Maternal folate deficiency may result in general impairment of fetal growth,which is reflected in low birth weight.Such women also have a high incidence of abortion,abruptio placentae and fetal malformation.Folate supplemented in pregnant women with the appropriate dose can reduce the risk of diseases such as birth defects and adverse pregnancy.In this article,we discussed the relationship between polymorphisms of enzyme genes involving folate metabolism and risk of birth defects such as congenital heart disease and neural tube defects,adverse pregnancy such as premature birth and abortion.