2012•Journal of Hubei University of MedicineRequires access

Transplantation of Adipose Mesenchymal Stem Cells Modified by BDNF Gene on Recovery of Motor Function after Acute Spinal Cord Injury in Rats

Sen Chen

Abstract

Objective To investigate the behavior changes of rats with acute spinal cord injure after treating with adipose mesenchymal stem(AMS) cells modified by BDNF gene and to evaluate the neural function recovery.Methods Total 60 rats were randomly divided into sham group,treatment group and control group.The rats model of spinal cord injury(SCI) was prepared with modified Allen method.AMS cells transplantation was performed at day 9,and 0.9% physiological saline was injected in control group.BBB scores and motor evoked potentials(MEPs) were performed on day 1,3,7 and 21 after transplantation.Results BBB scores in the treatment group was higher than in control group on day 7 after transplantation(P0.05).MEPs were significantly enhanced in the treatment group compared with control group.Conclusion The transplantation of AMS cells modified by BDNF gene can promote the recovery of motor function in rats with acute spinal cord injury.

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Key concepts: Transplantation, Spinal cord injury, Medicine, Mesenchymal stem cell, Spinal cord, Adipose tissue, Saline, Motor function