The Clinical analysis of 165 patients with ambiguous genitalia in disorders of sex development

Objective To investigate the diagnosis and treatment of ambiguous genitalia in disorders of sex development.Methods The clinical setting of the 165cases of patients with ambiguous genitalia was retrospective analyzed and the etiology and clinical diagnosis and treatment were summarized.Results Among the 165cases of ambiguous genitalia,28cases(17.0%)were congenital adrenal hyperplasia,3cases(1.8%)were because of exogenous androgen excess in the early stages of pregnancy,69cases(41.8%)were imcomplete androgen insensitivity syndrome,56cases(33.9%)were 45,XO/46,XY mixed gonadal dysgenesis,7cases(4.2%)were true hermaphroditism and 2cases(1.2%)were testicular regression syndrome.All of the patients underwent genital plastic surgery,and 133cases underwent gonadectomy.Conclusion As multiple etiologies can cause ambiguous genitalia,a clinical comprehensive consideration of etiology,external genital development,chromosome and gonads,social gender,psychological and personal wish is important before the vulva plastic surgery and individual treatment.