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2012•Zhongguo linchuang jiepouxue zazhiRequires access

Effects of ischemic acute kidney injury on ultrastructure of rat lung

Bao Cui-fen

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Abstract

Objective To observe the ultrastructural changes of damaged lung induced by ischemic acute kidney injury(IAKI) in rats.Methods Transmission Electron Microscopy and morphometric analysis were used in this study.Results Both type I and II alveolar cells undergoing necrosis could be seen in the lungs damaged by IAKI.Disappeared osmiophilic multilamellar bodies of damaged type II cells could be found.In addition,endothelial cells undergoing apoptosis were also noted in the lungs damaged by IAKI.Neutrophilic leukocyte infiltration was evident in alveolar septum with IAKI.Conclusions Both necrosis and apoptosis are involved in the lungs damaged by IAKI,but necrosis is more evident than apoptosis.Leukocyte infiltration is also involved in the lungs of RIRI animals.

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Objective To observe the ultrastructural changes of damaged lung induced by ischemic acute kidney injury(IAKI) in rats.Methods Transmission Electron Microscopy and morphometric analysis were used in this study.Results Both type I and II alveolar cells undergoing necrosis could be seen in the lungs damaged by IAKI.Disappeared osmiophilic multilamellar bodies of damaged type II cells could be found.In addition,endothelial cells undergoing apoptosis were also noted in the lungs damaged by IAKI.Neutrophilic leukocyte infiltration was evident in alveolar septum with IAKI.Conclusions Both necrosis and apoptosis are involved in the lungs damaged by IAKI,but necrosis is more evident than apoptosis.Leukocyte infiltration is also involved in the lungs of RIRI animals.

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Available abstract

Objective To observe the ultrastructural changes of damaged lung induced by ischemic acute kidney injury(IAKI) in rats.Methods Transmission Electron Microscopy and morphometric analysis were used in this study.Results Both type I and II alveolar cells undergoing necrosis could be seen in the lungs damaged by IAKI.Disappeared osmiophilic multilamellar bodies of damaged type II cells could be found.In addition,endothelial cells undergoing apoptosis were also noted in the lungs damaged by IAKI.Neutrophilic leukocyte infiltration was evident in alveolar septum with IAKI.Conclusions Both necrosis and apoptosis are involved in the lungs damaged by IAKI,but necrosis is more evident than apoptosis.Leukocyte infiltration is also involved in the lungs of RIRI animals.

Key concepts: Necrosis, Ultrastructure, Pathology, Infiltration (HVAC), Lung, Apoptosis, Kidney, Biology

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