The promotion effects of chitosan on infected wound healing in diabetic rats

Objective To investigate the effects of chitosan on the infected wound healing in diabetic rats.Methods The Wistar rats were used to make the models of the diabetes,a round skin wound was established on the dorsal backs of rat.And then the rats were divided into groups: the test group was treated with 5% chitosan group.The total amount of bacteria,the healing rate of wound and the concentration of TGF-β1 in the wounds were observed and compared with the model group.Results and Conclussion At the 7,14 and 21 day,the healing rate of 5% chitosan group was higher than that of diabetes control group,and reached to 100% in the 21 day;The total amount of bacteria of the 5% chitosan group was remarkably less than that of diabetes control group at the 3 and 7 day;the concentration of TGF-β1 in 5% chitosan group was significantly higher than that in diabetic model group at the 3,7 and 14 day.Results shows that 5% chitosan can promote the healing of the infected wound in diabetic rats,the excellent antibacterial functions of chitosan and increased amount of TGF-β1 in the wound would be probably considered an important reason.