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Research Advancement on Transforming Growth Factor β and Osteoarthritis

Bao Tong-zh

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Abstract

Transforming growth factor-β(TGF-β)play an important role in chondrocyte metabolism,which participate in cartilage matrix secretion,proliferation,bone formation and differentiation,and bone cytopoiesis and chondrogenesis can be enhanced by intra-articular injection of TGF-β.The pathological changes of osteoarthritis is associated with TGF-β,which take part in destroy of chondrocyte,degradation of dartilage matrix,synovial inflammation and osteophyte formation.

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What this paper is about

Transforming growth factor-β(TGF-β)play an important role in chondrocyte metabolism,which participate in cartilage matrix secretion,proliferation,bone formation and differentiation,and bone cytopoiesis and chondrogenesis can be enhanced by intra-articular injection of TGF-β.The pathological changes of osteoarthritis is associated with TGF-β,which take part in destroy of chondrocyte,degradation of dartilage matrix,synovial inflammation and osteophyte formation.

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Available abstract

Transforming growth factor-β(TGF-β)play an important role in chondrocyte metabolism,which participate in cartilage matrix secretion,proliferation,bone formation and differentiation,and bone cytopoiesis and chondrogenesis can be enhanced by intra-articular injection of TGF-β.The pathological changes of osteoarthritis is associated with TGF-β,which take part in destroy of chondrocyte,degradation of dartilage matrix,synovial inflammation and osteophyte formation.

Key concepts: Osteoarthritis, Chondrogenesis, Transforming growth factor, Chondrocyte, Cartilage, Articular cartilage, Bone matrix, Subchondral bone

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