Clinical observation of FOLFOX4 regimen for advanced gastric cancer

Aim To observe the efficacy and toxicity of using oxaliplatin(L-OHP) in combination with 5-fluorouracil(5-FU) and calciumfolinate(CF)(FOLFOX4 regimen) in treatment of advanced gastric cancer.Methods A total of 26 advanced gastric cancer patients re-ceived FOLFOX4 regimen by administering L-OHP 85 mg.m-2 intravenous infusion dl,CF 200 mg.m-2 intravenous infusion lastingtwo hours dl,2,and then 5-Fu 400 mg.m-2 bolus infusion followed by 600 mg.m-2 continuous intravenous infusion lasting twenty-two hours d1,2 every fourteen days.WHO standard was used to evaluate clinical efficiency and toxic reaction,and Levi special standard was used to evaluate peripheral nerve toxicity.Results A median of 3.5 cycles(range,2～6) chemotherapy per patient had been adminis-tered,and the response rate of all the patients were evaluated.The best response rates were 1 complete response(CR),10 partial response(PR),7 stable disease(SD),and progression of disease(PD) happened in other 8 patients.The overall response rate was 42.3% and disease control rate was 69.2%.The median time to progression(TTP) was 5.1 months(range,3～14 months),and the median over allsurvival(OS) was 7.2 months(range,3.2～18 months).The major toxic reaction included neutropenia 46.2%(12 /26),peripheral nerve toxicity 42.3%(11 /26),nausea and vomiting 30.8%(8 /26) and diarrhea 19.2%(5 /26) respectively.Most of the severity of theseeffects was grade 1～2 and well tolerated.Conclusion The FOLFOX4 regimen was effective in advanced gastric cancer with acceptable toxicity,It is worthy to be further used and studied clinically.