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Double filtration plasmapheresis in highly sensitive kidney recipients

Yimin Wang

Abstract

Objective To evaluate doulbe filtration plasmaphoresis (DFPP) for highly sensitive kidney recipients. Methods DFPP was carried out before kidney transplantation for 19 highly sensitive recipients 〔Panel reactive antibody (PRA)40%〕. Results In 13 patients,the PRA level decreased from (59.1±14.1)% to (19.2±18.9)% ( P 0.05),decreased by an average of (40.1±19.2)%. In the other 4 patients,PRA turned negative (PRA10%).17 of them underwent renal transplantation.Hyperacute rejection occurned in 1.Acute rejection occurned in 6 but reversed on antirejection therapy. Conclusions DFPP renders the highly sensitive patients the chance of transplantation.It not only reduces the incidence of rejection but also increased the success rate of antirejection therapy.Long term outcome of the graft and patient is satisfactory.

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Key concepts: Plasmapheresis, Panel reactive antibody, Medicine, Kidney transplantation, Renal function, Urology, Transplantation, Incidence (geometry)